Drug use memories and relapse: Can medication provide addiction help?
October 26, 2009 – 7:07 amAbout a year ago, while sitting in a lecture on learning and memory, the idea that certain drugs can affect the emotional responses to memory long after the memory itself has been formed came up. As someone interested in addiction research, the implication for treatment immediately came up in my head:
Could we reduce the effect of triggers by giving people a pill?
In one word – Yes! But, the answer is not, in fact, that simple. Even in the studies already done in PTSD patients, the memories have to be re-triggered and the drug given at exactly the right time to be effective. In fact, in humans, some of the best work has been done in PTSD patients immediately after the traumatic event.
Addiction help through relapse prevention
Still, a recent study in animals suggests that the theory is sound. By interfering with the activity of a neurotransmitter important in the formation of memories, researchers were able to stop animals trained to self-administer cocaine from doing so. The animals, which had been trained to push a lever for cocaine when a light went on, reduced, or even stopped responding after a single dose of a substance that blocked memory formation. Essentially, the researchers prevented the animals from relapse. Again, this only worked if the drug was given while the light (as in the drug-trigger) was presented at the same time.
More recent studies, using repeated doses of the drug propranolol, have been shown to have an even more promising effect. Check out my coverage of that research here.
Given the powerful role of triggers in relapse, this avenue of research has some promising possibilities for future treatment of drug addiction.
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Tags: addiction help, Animal research, animals, cocaine, drug-trigger, medication, neurotransmitter, propranolol, PTSD, rats, rehab, relapse, treatment, trigger
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